This group of tumors has the appearance of stage I or ii endometrial adenocarcinoma. The predominant growth model is glandular papillary or less fluently. The cells that line are large, columnar, and densely eosinophilic cytoplasm or basophil. Sometimes mature metaplastic squamous cells occur in neoplastic glands. infiltrating carcinoma contains tall columnar cells with pseudostratified nuclei, eosinophils and basophils, and squamous metaplasia of area within the gland of the tumor.
The age distribution is bimodal peak, a 20-year and one in the fifth and sixth years of life. 75 the most common complaint is vaginal bleeding and, after examination, a polypoid, exophytic or budding tumor is visible. 76 approximately two thirds ib stage Figo and the rest are ii or higher stage. In the offspring of exposed, clear cell carcinoma of the cervix are located mainly in the ectocervix and endocervical rarely. Under the microscope, the tumor cells have clear cytoplasm appears separate vacuum and enlarged the hyperchromatic nuclei, which project in the apical cytoplasm, the so-called hobnail appearance.
The clear cytoplasm is attributed to the abundant glycogen accumulation appearance similar to that observed in endometrial secretory cells. The most favorable outcome is associated with tubulocystic pattern, followed by papillary and solid grounds. This mass of exophytic tumor endocervix is characterized by papillary growth pattern. Tumor stroma consists of fibrohyalinized bordered by intermediate to large tumor cells with clear cytoplasm and pink, high quality cores and appearance of hobnail. Depth of stromal invasion, stage of Figo and pelvic lymph node status are key prognostic indicators.
Rare cases of recurrence occurred 20 years after treatment. Metastases to lung and supraclavicular lymph nodes were more common than squamous cell carcinoma. Some adenocarcinomas indistinguishable from a papillary serous ovarian carcinoma have been reported. 79 tumor has microscopically a complex pattern of buds with cellular sprouting and glands with slot-shaped spaces. Nearly half of the cases have a second mixed pattern, usually of low grade adenocarcinoma villoglandular but endocervical, clear cell and endometrioid adenocarcinoma can be mixed.
The diagnosis of serous adenocarcinoma of the cervix can be performed when metastases of ovarian, endometrial, and the peritoneum are excluded. A useful point is that the serous adenocarcinoma of the cervix is often CEA positive contrast to this tumor when occurring in other sites. Tumor grows in a papillary pattern and ranged from fibrovascular stroma sizes lined with high-quality kernels. Intestinal type adenocarcinomas is composed of cells similar to those observed in colorectal adenocarcinomas, characterized by the presence of goblet cells. neuroendocrine cells and sometimes Paneth cells may be present. change of intestinal type can be found only diffusely or focally in a mucinous carcinoma.
The main differential diagnosis is metastatic intestinal adenocarcinoma. neck of the uterus of primary intestinal adenocarcinomas type is generally reactive with cytokeratin 7 and does not react with cytokeratin 20 and cdx2. intermediate power shows infiltrating adenocarcinoma with glandular growth pattern. The tumor cells contain intracytoplasmic mucin abundant with dentate nuclei. 65 cells contain abundant eosinophilic cytoplasm and evidence of keratinization of individual cells. Sometimes, squamous cells with clear cytoplasm abundant glycogen. glandular formation is evident in most adenocarcinomas. Adeno carcinoma well differentiated type of collar.
Squamous cell carcinoma Nonkeratin interspersed with cell differentiation and mucinous columnar luminal. Most carcinomas Mesonephric channel reported previously belong to the category of adenocarcinoma clear cell by the current classification. An important diagnostic feature is the presence of eosinophilic hyaline material in the light, which is positive with negative staining and with Mucicarmine spot.