Cervical ectropion silver nitrate treatment
Five women were alive and well, and three died of other causes. Late recurrence and metastasis have been known to occur. circumscribed carcinoma of the cervix was described in 1977 by Hasumi and associates.
47 in their study, tumors were characterized by strong ropes with cell differentiation or squamous or glandular, surrounded by a dense lymphocytic infiltrate, which sometimes contained a considerable number of eosinophils and plasma cells. The tumor cells were fairly monomorphic, with large nuclei, one or more nucleoli and clear to eosinophilic granular cytoplasm.
Similar studies, if not identical, tumors lymphoepithelioma use the term to indicate the histologic resemblance to lymphoepithelioma nasopharyngeal lymphoid lesions and malignant salivary gland. Although the total number of cases in the literature is too small for a full understanding of these neoplasms, they seem to have a better prognosis than conventional squamous cell carcinoma. After radical hysterectomy all 15 patients were alive and well.
Squamous cells of the spindle is a rare variant of poorly differentiated cancer that may be confused with either melanoma or sarcoma. keratin formation and the typical nesting grounds epithelial tumors may be absent. stromal changes such as deposition of heavy collagen can give the appearance of a fibrosarcoma and osteosarcoma. Faced with such a lesion, electron microscopy or immunohistochemistry is often necessary to identify the epithelial nature. A positive immunohistochemical stain for cytokeratin and demonstration of desmosomes and tonofilaments electron microscopy distinguish these lesions of mesenchymal tumors. the elongated tumor cells are arranged in bundles that simulate sarcoma cells of the spindle.
One can also see that rarely abnormal spindle cells in the cervical stroma adjacent to a typical squamous cell carcinoma. This so-called pseudosarcoma was reported by Watty and colleagues who described 52 atypical stromal individual cells with elongated, polymorphic nuclei and frequent multinucleation. The authors estimate that this change was a response to the nearby tumor and noted that similar lesions have been reported in squamous cell carcinomas of the head area and neck. endocervical dysplasia and adenocarcinoma in situ. endocervical adenocarcinoma in situ recognition is important for the clinical management of patients and the risk of recurrence and tumor progression.
However, the distinction between endocervical glandular lesions benign, dysplastic, and really carcinoma in situ of the endocervix can be difficult and sometimes very difficult. 53 established a three-tiered rating system for differentiating benign and dysplastic endocervical adenocarcinoma in situ endocervical. glandular dysplasia scoring system and carcinoma in situ 53.
17 these lesions are detected in specimens removed for adenocarcinoma in situ or cytology of atypical glandular cells of undetermined significance in. In samples of endocervical curettage and samples of cervical biopsy, endocervical cells present with atypical nuclear enlargement, irregular, and multinucleation in a chronic cervicitis context. The adjacent squamous mucosa may have warts or low-grade dysplasia.
17 these changes are likely reactive atypia and have a malignant potential. Moreover, dysplastic glands lined by endocervical cells with moderate or severe degrees of nuclear atypia, the hyperchromatic nuclei enlarged, two to three laminated layers and increased mitotic activity are potential precursors of adenocarcinoma. dysplastic change also occurs in the glands lined Metaplastic tubal hair cells. The morphological criteria and the biological potential of glandular dysplasia remain undefined.
The entity of cervical adenocarcinoma in situ has been widely accepted and recognized as the precursor of invasive adenocarcinoma. 17 endometrioid and clear cell type 14 adenocarcinoma in situ have also been described.