Lesiones cervicales ectropion
Occasionally, squamous cell carcinoma and adenocarcinoma coexisting with neuroendocrine carcinoma. The prognosis of this group of tumors is related to the extent of the disease and the degree of differentiation. Poorly differentiated tumors are very aggressive with a propensity for local and distal spread. 96 A recent study of 31 neuroendocrine tumors of the cervix shows that the average survival time for all patients was 323 months. The tumor cells are small oval and spindle with a little cytoplasm and hyperchromatic nuclei.
Other malignancies Mullerian cervix. Some rare malignancies of mullerian origin can develop in the cervix as well. All these tumors show similar histology as seen in their counterparts of the uterus, fallopian tubes and ovaries. Overall, carcinosarcoma and leiomyosarcoma more aggressive adenosarcoma and stromal sarcoma way. Recognition of these rare entities is useful for early detection and appropriate medical treatment.
It appears that the differentiation of the epithelium of carcinosarcoma in the neck differs from its counterparts of the uterus and ovaries. Reported eight cases of carcinosarcoma in the cervix. Invasive epithelial component was composed of basal carcinoma combined adenoids, basaloid SCC, and adenoid cystic carcinoma in two cases. Keratinizing SCC, large cell non-keratinizing SCC, undifferentiated carcinoma and basaloid SCC predominated in the remaining tumors, one of which had a mixed Adenocystic carcinoma.
The sarcomatous component was homologous and spindled with myxoid areas mixed in three injuries. Five tumors were vimentin positive epithelial component. the polymerase chain reaction detected HPV DNA in the eight cases. In situ hybridization probes for HPV types 6, 11, 16, 18, 31, 16 and 33 demonstrated built in three cases hpv. We have a collection of two cases with carcinosarcoma in the cervix.
Leiomyosarcoma this neck is composed of tumor cells with atypical nuclei and polymorphic epithelioid. highlighted cells are normal endocervical epithelium. Stromal cells have mild cytologic atypia with mitosis until five to 10 high power field. Focally highlighted normal endocervical epithelium can be seen at the top. Tumor is composed of mostly bland spindle and oval cells in a myxoid matrix. thick and thin-walled vessels with hyalined changes are present. A tumor infiltrating growth profile in the neck.
This cervical biopsy is completely replaced by malignant lymphocytes with necrosis of the tumor. Tumor is a cytotrophoblaststic cell sheet with areas of hemorrhage and sprinkled syncytiotrophoblastic cells. cytotrophoblastic cells are polygonal cells and medium sized round with cytoplsm amphophilic. A normal endocervical gland is on the right side. Finally secondary tumors metastatic cervical occur most often in the direct extension of an adjacent malignancy, such as the endometrium and vagina. In recent years, several large series have used statistical models to identify important prognostic parameters of cervical carcinoma in women treated by radical surgery and radiotherapy. In the study of Sevin and associates 100 370 women with stage i or ii carcinoma were treated with radical hysterectomy and pelvic lymphadenectomy.
In univariate analysis, disease-free survival rates were closely related to the depth of stromal invasion, the tumor size, the presence or absence of lymph node involvement vascular space, pelvic lymph node status , the tumor volume and clinical stage. Kamura and colleagues studied 101,211 women with stage Ib and ii cervical carcinoma treated with radical hysterectomy and pelvic lymphadenectomy. The histological grade was not assessed in this study. A decrease in survival was strongly related to the presence of pelvic metastases in the lymph nodes. 102 among lymph node-negative cases, cell type adenocarcinoma, which increases the size of the tumor, deeper stromal invasion and poor histologic grade have been associated with decreased survival.
102 size increase of the tumor and the depth of invasion and histological grade were covariates and predictors of both lymph node metastasis and recurrence. 102 in this study, poorly differentiated tumors had the size of the largest tumor.