It should be noted that the benign adenomatous hyperplasia of the mesonephric duct lies deep in the cervical stroma, mimicking adenoma malignum and mesonephric adenocarcinoma. intraluminal eosinophilic hyaline material are obvious. These tumors presented with a variety of growth patterns, including ductal, tubular, retiform, solid, and sex cord-like structures. Rarely pin endometrial stromal sarcoma cells looked and contained osteoid and chondroid metaplasia. Two of the five women underwent pelvic lymph node dissections had micrometastases.
82 monitoring data indicated that three women were alive and well, two experienced recurrences, and one of the dead unrelated clear cell carcinoma of the ovary. This tumor is solid nests and leaves tumor cell non-keratinizing resembling a squamous cell carcinoma. A closer examination, there are additional cells, which basophils, clear or vacuolated cytoplasm and nuclei compressed, resembling signet ring cells. 65 with Mucicarmine spot, the presence of mucinous product can be confirmed.
This distinction is important because there is a difference in the risk of pelvic lymph node metastases. 85 these results suggest that the squamous cell carcinoma with mucin production has a more aggressive behavior than conventional squamous cell carcinoma. The tumor cells of this type have abundant eosinophilic, granular, and ground glass cytoplasm, the borders of bright cells, uniformly round to oval nuclei and nucleoli giants. Many eosinophils and plasma cells are noted in the stroma. In the original description of this entity, the tumor cells were positive 80 not material, but no mucinous substance.
However, in the study of maier and norris 86 September eight tumors studied by Mucicarmine spot were positive. Three of the eight neoplasms content glandular lumens, and three others had squamous differentiation. Electron microscopic study glaze matched polyribosome and abundant rough endoplasmic reticulum. 87 although no intracytoplasmic lumens were identified, there was intercellular spaces lined with microvilli to suggest glandular differentiation. Some tumor cells also contain a mucinous material in the cytoplasm. 87 These ultrastructural and histochemical findings support the undifferentiated nature of these tumors and the presence of glandular differentiation in certain tumor cells.
87 tumor cells are reactive to low and high molecular weight cytokeratin, MUC1 and muc2 but negative for estrogen or progesterone. adenoid cystic carcinoma of the lower female genital tract occurs most often in the Bartholin gland. It is followed by the cervix, which primarily affects postmenopausal women in their seventh decade of life, about 20 years later than squamous cell carcinoma. The histological features are similar to those which occur in the salivary gland. It is suggested that the pluripotent cells of the endocervical glands in reserve acquire myoepithelial differentiation, which are not normally seen in the cervix. Histologically, basaloid cells are usually arranged in the cribriform glands with hyaline or mucinous material in Microcystic spaces. Tumors with predominantly solid growth models can metastasize early.
Individual cells were rare and little cytoplasm, uniform, hyperchromatic nuclei. mitotic figures are variable depending on the degree of differentiation. This invasive carcinoma displays a large nesting and solid growth models. basaloid cells form most cribriform glands with amphiphilic hyaline material in the light. In such cases, squamous cells replace the glandular light partially or completely. When predominantly squamous items, adenoid cystic carcinoma can not be recognized in a small biopsy sample.
Other types of adenocarcinoma, undifferentiated carcinoma, or sarcoma can sometimes coexist with adenoid cystic carcinoma. None of the patients with stage III or IV disease survived. 90 in a recent review, the tumors to a large early stage are best treated with combined surgery and postoperative radiotherapy and chemotherapy with cisplatin.